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Translational Medicine / 转化医学BET Inhibitor IO Combinations, Epigenetic Cancer Therapy

Konstantinos Elenitoba-Johnson

MD

🏢University of Pennsylvania / Perelman School of Medicine🌐USA

Professor and Chair, Pathology and Laboratory Medicine

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👥Biography 个人简介

Konstantinos Elenitoba-Johnson is a molecular pathologist and cancer biologist who has contributed to understanding BET bromodomain inhibitors (BETi) including JQ1 and its analogs as epigenetic therapies that suppress MYC-driven oncogene programs and modulate PD-L1 expression, providing a mechanistic rationale for BETi+PD-1 inhibitor combinations. His laboratory studies transcriptional dependencies in hematologic malignancies and has characterized how BRD4 inhibition can reprogram the tumor microenvironment to enhance immunotherapy efficacy, particularly in lymphoma and AML.

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🧪Research Fields 研究领域

BET bromodomain inhibitor JQ1 OTX015
BET inhibitor immunotherapy combination
MYC BET inhibitor suppression cancer
BRD4 chromatin reader cancer therapy
BET inhibitor lymphoma hematologic malignancy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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