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Translational Medicine / 转化医学T-DXd HER2 Esophageal/Gastric

Kohei Shitara

MD

🏢National Cancer Center Hospital East🌐Japan

Department Chief, GI Oncology

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Key Contributions

👥Biography 个人简介

Kohei Shitara at the National Cancer Center Hospital East has led pivotal trials of antibody-drug conjugates and targeted therapies in gastric and esophageal cancers. He was the principal investigator of DESTINY-Gastric01, demonstrating trastuzumab deruxtecan efficacy in HER2-positive gastric/GEJ cancer after prior trastuzumab, leading to regulatory approval. His work defines the modern treatment landscape for HER2-altered upper GI cancers.

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🧪Research Fields 研究领域

T-DXd HER2 gastric esophageal
DESTINY-Gastric trials
HER2-low gastric cancer
ADC gastric cancer
FOLFOX gastric Japan

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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