Michael Knisely

Michael Knisely has investigated the abscopal effect in the context of brain metastases and CNS tumors, exploring whether stereotactic radiosurgery combined with immunotherapy can generate systemic immune responses from intracranial treatment sites despite the blood-brain barrier. His clinical observations and research have contributed to understanding the unique immunological consequences of CNS-directed radiation. He develops protocols combining stereotactic radiosurgery with immune checkpoint inhibitors for patients with brain metastases.