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Translational Medicine / 转化医学Multi-Cancer Screening Trials

Eric Klein

MD

🏢Cleveland Clinic / GRAIL🌐USA

Professor Emeritus of Urology

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👥Biography 个人简介

Eric Klein led the landmark PATHFINDER study evaluating the Galleri multi-cancer early detection test in a prospective clinical setting, demonstrating that a single blood test could detect over 50 cancer types with high specificity in asymptomatic individuals. His work established the clinical workflow for MCED test-positive patients, showing that cancer signal origin prediction accurately guided diagnostic workup. His research has been instrumental in defining the evidence standards required for population-level implementation of blood-based multi-cancer screening.

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🧪Research Fields 研究领域

PATHFINDER study design
Multi-cancer early detection trials
Galleri test clinical validation
cfDNA methylation screening
Cancer screening implementation

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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