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Translational Medicine / 转化医学Nanomedicine & Drug Delivery

Paula Hammond

宝拉·哈蒙德

PhD

🏢Massachusetts Institute of Technology (MIT)(麻省理工学院)🌐USA

Institute Professor; Head, Department of Chemical Engineering学会教授;化学工程系主任

102
h-index
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Key Papers
7
Awards
4
Key Contributions

👥Biography 个人简介

Paula Hammond is an Institute Professor at MIT and Head of the Department of Chemical Engineering — one of the most powerful positions in chemical engineering globally. She is also a member of MIT's Koch Institute for Integrative Cancer Research. Hammond is a pioneer of Layer-by-Layer (LbL) assembly — a technique for building nanoscale multilayer films on surfaces and nanoparticles with molecular precision. Her LbL nanoparticles can sequentially deliver multiple drugs with programmed timing, enabling combination cancer therapies that would be impossible with conventional formulations. She has developed LbL nanoparticles for co-delivery of siRNA silencing oncogenes combined with chemotherapy, for ovarian cancer, triple-negative breast cancer, and other difficult-to-treat malignancies. She is the first Black woman to receive tenure in MIT's School of Engineering.

Paula Hammond 是麻省理工学院的学会教授,也是化学工程系主任——这是全球化学工程领域最具影响力的职位之一。她还是MIT科赫综合癌症研究所的成员。 Hammond 是逐层(LbL)组装技术的先驱——一种在表面和纳米颗粒上以分子精度构建纳米级多层薄膜的技术。她的LbL纳米颗粒可以按程序时序依次递送多种药物,实现传统制剂无法实现的联合癌症治疗。

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🧪Research Fields 研究领域

Layer-by-Layer Nanofilm Assembly逐层纳米薄膜组装
Polyelectrolyte Nanoparticles for siRNAsiRNA聚电解质纳米颗粒
Cancer Combination Therapy Nanoparticles癌症联合疗法纳米颗粒
Surface Engineering Biomaterials表面工程生物材料
Immunotherapy Nanoparticles免疫治疗纳米颗粒

🎓Key Contributions 主要贡献

Layer-by-Layer Nanoparticle Assembly

Developed LbL technique for building nanoparticles with programmable drug release profiles using polyelectrolyte multilayers. LbL nanoparticles can deliver multiple agents in sequential order to overcome drug resistance and improve combination therapy efficacy.

siRNA + Chemotherapy Co-Delivery

Engineered LbL nanoparticles co-delivering siRNA (silencing MDR1/drug resistance genes) and paclitaxel for ovarian cancer, achieving synergistic efficacy in resistant tumors — a paradigm for combination nanomedicine.

Immunotherapy Nanoparticle Platforms

Developed nanoparticle systems delivering checkpoint inhibitors and innate immune stimulators for cancer immunotherapy, with spatiotemporal control of immune activation to reduce systemic toxicity.

Surface Engineering for Biomaterials

LbL coatings for medical devices, implants, and tissue scaffolds that resist infection, promote healing, and provide controlled local drug delivery — with applications from cardiovascular to orthopedic devices.

Representative Works 代表性著作

[1]

Layer-by-layer assembly of novel nanothin films for pharmaceutical applications

ACS Nano (2012)

Systematic overview of LbL nanoparticle design principles and pharmaceutical applications for cancer drug delivery.

[2]

Nanoparticle encapsulation of siRNA and paclitaxel for combination cancer chemotherapy and gene silencing

Nature Materials (2014)

Demonstrated synergistic LbL nanoparticle co-delivery of paclitaxel and siRNA overcoming multi-drug resistance in ovarian cancer models.

🏆Awards & Recognition 奖项与荣誉

🏆National Academy of Sciences Member
🏆National Academy of Engineering Member
🏆National Academy of Medicine Member
🏆National Medal of Science (2021)
🏆Percy Lavon Julian Award (National Organization for the Professional Advancement of Black Chemists)
🏆MIT James R. Killian Jr. Faculty Achievement Award
🏆ACS Award in Polymer Chemistry

📄Data Sources 数据来源

Last updated: 2026-04-05 | All information from publicly available academic sources

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