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Translational Medicine / 转化医学CAR-T Therapy, GPC3 Liver Cancer

Kiyoko Bhatt

MD, PhD

🏢National Cancer Center Japan🌐Japan

Professor of Oncology

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Key Contributions

👥Biography 个人简介

Kiyoko Bhatt is a pioneer in GPC3-targeted CAR-T cell therapy for hepatocellular carcinoma, one of the most common liver cancers globally. Her research demonstrated that GPC3 is highly expressed in HCC with minimal normal tissue expression, making it an ideal CAR-T target. She has developed novel CAR constructs with enhanced specificity and anti-HCC activity. Her clinical trials have shown promising responses in advanced HCC patients who failed sorafenib and immunotherapy.

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🧪Research Fields 研究领域

GPC3 CAR-T
hepatocellular carcinoma
liver cancer immunotherapy
glypican-3
solid tumor cell therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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