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Translational Medicine / 转化医学Epigenetic Clock and Biological Aging

James Kirkland

MD, PhD

🏢Mayo Clinic🌐USA

Professor of Medicine and Director of Robert and Arlene Kogod Center on Aging

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Key Contributions

👥Biography 个人简介

James Kirkland pioneered senolytic therapy, demonstrating that selective elimination of senescent cells with dasatinib plus quercetin reverses multiple age-related conditions and reduces epigenetic age acceleration in clinical trials. His work establishing that senescent cell burden drives biological aging and cancer susceptibility has opened a new therapeutic paradigm in cancer prevention. He leads the geroscience approach to simultaneously targeting aging and cancer through senescent cell clearance.

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🧪Research Fields 研究领域

Senolytic therapy development
Senescent cell clearance
Dasatinib plus quercetin
Geroscience and healthspan
Aging interventions

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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