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Translational Medicine / 转化医学NK Cell Therapy, ADCC and Antibody Synergy

Kerry S. Campbell

PhD

🏢Fox Chase Cancer Center, Temple University🌐USA

Professor; Co-Leader, Immune Cell Development and Host Defense Program

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👥Biography 个人简介

Kerry Campbell is a leading NK cell biologist who has made foundational contributions to understanding ADCC (antibody-dependent cellular cytotoxicity) mediated by NK cells via the CD16a (FcgRIIIA) receptor. His research has defined the molecular mechanisms by which NK cells recognize antibody-coated tumor cells and trigger cytotoxic responses. He has characterized polymorphisms in CD16a that influence ADCC efficiency and clinical responses to therapeutic monoclonal antibodies. His work provides the mechanistic basis for strategies to enhance antibody-NK cell synergy in cancer immunotherapy.

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🧪Research Fields 研究领域

NK cell ADCC
antibody-NK cell synergy
CD16a FcgRIIIA
NK cell co-stimulation
NK cell receptor biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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