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Translational Medicine / 转化医学HER2 Signaling Biology, Drug Development

Kenneth Bhatt

PhD

🏢Genentech / Roche🌐USA

Senior Research Scientist

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Key Contributions

👥Biography 个人简介

Kenneth Bhatt has contributed to the molecular understanding of HER2 receptor biology and the development of novel HER2-targeting biologics. His research characterized the structural basis of HER2 dimerization and how pertuzumab disrupts HER2-HER3 heterodimerization to block PI3K-AKT signaling. He has also investigated biparatopic HER2 antibodies that simultaneously bind two non-overlapping HER2 epitopes for enhanced receptor downregulation. His industry contributions have accelerated the development of next-generation HER2-targeting therapeutics.

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🧪Research Fields 研究领域

HER2 dimerization
PI3K AKT signaling HER2
ERBB2 structure
biparatopic HER2 antibodies
zanidatamab

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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