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Translational Medicine / 转化医学Melanoma, BRAF MEK Targeted Therapy

Keith Flaherty

MD

🏢Massachusetts General Hospital🌐USA

Director of Clinical Research, Cancer Center

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Key Contributions

👥Biography 个人简介

Keith Flaherty led the pivotal trials that established BRAF inhibition (vemurafenib) and BRAF plus MEK inhibitor combinations (dabrafenib plus trametinib) as transformative treatments for BRAF V600E-mutant melanoma. His basic-to-clinical translational work defined the molecular basis of acquired resistance to BRAF inhibitors and prompted the development of rational combination strategies. He has also pioneered genomically driven clinical trial designs in oncology.

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🧪Research Fields 研究领域

BRAF inhibitors melanoma
MEK inhibitors melanoma
dabrafenib trametinib combination
vemurafenib BRIM-3
BRAF V600E molecular targeting

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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