Kathleen Moore
凯瑟琳·摩尔
MD, MS
Associate Director for Clinical Research; Professor of Gynecologic Oncology临床研究副主任；妇科肿瘤学教授
👥Biography 个人简介
Kathleen Moore, MD, MS is a leading gynecologic oncologist at the University of Oklahoma Stephenson Cancer Center. She led the landmark PRIMA trial establishing niraparib first-line maintenance in ovarian cancer, transforming care for HRD-positive patients. Her work defines the modern PARP inhibitor treatment paradigm.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PRIMA Trial / First-Line PARP Maintenance
Principal investigator of the PRIMA/ENGOT-OV26 trial demonstrating niraparib maintenance significantly improved progression-free survival in newly diagnosed advanced ovarian cancer, including HRD-positive patients.
Homologous Recombination Deficiency Biomarker Development
Advanced HRD testing strategies to identify patients most likely to benefit from PARP inhibitor maintenance, enabling precision selection in the first-line setting.
Representative Works 代表性著作
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer (PRIMA/ENGOT-OV26)
New England Journal of Medicine (2019)
Landmark phase III trial showing niraparib as first-line maintenance improved PFS across all patient populations, with greatest benefit in HRD-positive disease.
Bevacizumab plus niraparib as maintenance therapy in newly diagnosed advanced ovarian cancer
Journal of Clinical Oncology (2023)
Evaluated combined VEGF and PARP inhibition as maintenance strategy in the first-line setting for advanced ovarian cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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