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Translational Medicine / 转化医学Ovarian Cancer, Homologous Recombination Deficiency

Kathleen Moore

MD, MS

🏢University of Oklahoma Health Sciences Center🌐USA

Director, Drug Development Program

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👥Biography 个人简介

Kathleen Moore led the PRIMA trial establishing niraparib as first-line maintenance therapy in ovarian cancer, including HRD-high patients, at the University of Oklahoma. Her work has been central to defining HRD as a clinically actionable biomarker in ovarian cancer. She continues to investigate novel combinations and sequencing strategies involving PARP inhibitors and immunotherapy. She is a frequent educator and speaker on ovarian cancer management and biomarker-guided therapy.

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🧪Research Fields 研究领域

homologous recombination deficiency
niraparib PRIMA trial
ovarian cancer biomarkers
PARP inhibitor first line
genomic scar HRD testing

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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