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Translational Medicine / 转化医学LINE-1 Insertion Cancer, Somatic Retrotransposition

Kathleen Burns

MD, PhD

🏢Dana-Farber Cancer Institute / Harvard Medical School🌐USA

Professor of Pathology and Oncology

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👥Biography 个人简介

Kathleen Burns has made landmark contributions to understanding somatic LINE-1 retrotransposition in cancer. She developed methods to detect de novo LINE-1 insertions in tumor genomes and demonstrated that ORF1p protein serves as a pan-cancer biomarker. Her work revealed that LINE-1 insertions preferentially occur in genes critical for cancer development, establishing retrotransposition as an active mutagenic mechanism in tumorigenesis.

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🧪Research Fields 研究领域

somatic LINE-1 insertion
retrotransposon cancer genomics
ORF1p biomarker
colorectal cancer LINE-1
transposable element detection

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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