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Translational Medicine / 转化医学Prostate Cancer, mHSPC

Karim Fizazi

MD, PhD

🏢Institut Gustave Roussy🌐France

Professor of Medicine, Department of Cancer Medicine

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Key Contributions

👥Biography 个人简介

Karim Fizazi led the LATITUDE trial establishing abiraterone acetate plus prednisone with ADT as a standard of care for high-risk metastatic hormone-sensitive prostate cancer, demonstrating substantial overall survival benefit. His research has shaped the backbone of mHSPC treatment across multiple combination strategies. He has been a key investigator in trials examining abiraterone, darolutamide, and novel AR-targeted agents in hormone-sensitive disease. Fizazi's contributions to understanding prostate cancer biology and treatment sequencing are globally recognized.

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🧪Research Fields 研究领域

LATITUDE trial
abiraterone mHSPC
metastatic hormone-sensitive prostate cancer
high-risk mHSPC
AR pathway inhibition

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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