Karel Pacak
卡雷尔·帕恰克
MD, PhD, DSc
Senior Investigator and Chief, Section on Medical Neuroendocrinology资深研究员兼医学神经内分泌学科主任
👥Biography 个人简介
Karel Pacak at NIH/NICHD is a global authority on pheochromocytoma and paraganglioma (PPGL), leading landmark research on SDH-related hereditary syndromes, biochemical diagnosis, and novel imaging modalities. His work defined the genotype-phenotype landscape of PPGL and shaped international diagnostic criteria.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Genotype-Phenotype Correlations in PPGL
Established landmark correlations between germline mutations (SDHB, SDHD, VHL, RET, NF1) and tumor phenotype, biochemical secretion patterns, and malignant potential.
Biochemical Diagnosis Optimization
Championed plasma metanephrine measurement as the most sensitive and specific biochemical test for pheochromocytoma, now a global diagnostic standard.
Functional Imaging Advances
Led NIH studies validating 18F-DOPA and 18F-FDA PET/CT for PPGL localization, improving tumor detection particularly in SDH-mutated hereditary cases.
Representative Works 代表性著作
Pheochromocytoma: Recommendations for Clinical Practice from the First International Symposium
Nature Clinical Practice Endocrinology & Metabolism (2007)
Consensus recommendations establishing diagnostic biochemical algorithms and imaging strategies for pheochromocytoma management.
Succinate Dehydrogenase-Related Pheochromocytoma and Paraganglioma
Endocrine Reviews (2011)
Comprehensive review of SDH mutation spectrum, risk stratification, surveillance protocols, and treatment for hereditary PPGL syndromes.
Biochemical Diagnosis of Pheochromocytoma: Which Test Is Best?
JAMA (2002)
Landmark study demonstrating superiority of plasma free metanephrines over urinary catecholamines for pheochromocytoma diagnosis.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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