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Translational Medicine / 转化医学MALAT1, Nuclear Speckles, Cancer

Kannanganattu Prasanth

PhD

🏢University of Illinois Urbana-Champaign🌐USA

Professor, Cell and Developmental Biology

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Key Contributions

👥Biography 个人简介

Kannanganattu Prasanth has made key contributions to understanding MALAT1, one of the most abundantly expressed and cancer-relevant long non-coding RNAs, demonstrating its localization to nuclear speckles where it regulates alternative splicing and gene expression. His work revealed that MALAT1 overexpression promotes cancer metastasis through transcriptional and post-transcriptional regulation of metastasis-associated genes. He has contributed to understanding how MALAT1 serves as a prognostic biomarker across multiple cancer types. His research connects lncRNA nuclear biology with cancer progression mechanisms.

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🧪Research Fields 研究领域

MALAT1 lncRNA cancer
nuclear speckle RNA
MALAT1 metastasis
non-coding RNA nuclear organization
lncRNA splicing regulation cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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