Kai-Keen Shiu

Kai-Keen Shiu is a specialist in mismatch repair deficient cancers and POLE-mutated hypermutated tumors across gastrointestinal malignancies. His clinical research focuses on optimizing immunotherapy strategies for MSI-H and POLE-mutant cancers, understanding mechanisms of resistance, and identifying biomarkers of response. He has contributed to international trials in colorectal and other gastrointestinal cancers with mismatch repair deficiency. He works to translate biomarker discoveries into patient selection algorithms and therapeutic development strategies.