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Translational Medicine / 转化医学VHL, HIF, and Oxygen Sensing

William Kaelin

MD

🏢Dana-Farber Cancer Institute / Harvard Medical School🌐USA

Professor of Medicine

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Key Contributions

👥Biography 个人简介

William Kaelin shared the 2019 Nobel Prize in Physiology or Medicine for defining how cells sense and adapt to oxygen availability, particularly through the VHL-HIF axis. His work underpins the clinical use of HIF-2alpha inhibitors in VHL-associated renal cell carcinoma. He continues to lead translational research on synthetic lethality and oncometabolism.

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🧪Research Fields 研究领域

VHL
HIF
oxygen sensing
renal cell carcinoma
Nobel Prize 2019

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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