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Translational Medicine / 转化医学RB Pathway, Cell Cycle Cancer

Julien Sage

PhD

🏢Stanford University🌐USA

Professor

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Key Papers
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Key Contributions

👥Biography 个人简介

Julien Sage at Stanford has contributed to understanding the RB (retinoblastoma) pathway in cancer, including how CDK4/6-mediated phosphorylation of RB controls cell cycle entry and how loss of the RB pathway drives cancer proliferation. His work on the biological basis for CDK4/6 inhibitors (now standard of care in hormone receptor-positive breast cancer) and on RB pathway restoration as a therapeutic strategy has been influential.

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🧪Research Fields 研究领域

RB tumor suppressor cancer
CDK4-6 inhibitors RB
RB pathway breast cancer
cell cycle cancer
p16-CDK-RB axis

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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