Julien Sage

Julien Sage is a leading expert in RB1 tumor suppressor biology whose work has clarified how retinoblastoma protein loss promotes cell cycle entry and cancer development across multiple tumor types. His studies have revealed the complex interplay between RB1, CDK4/6 inhibition, and downstream transcriptional programs. He has characterized RB1 loss as a key event in small cell lung cancer transformation and resistance to CDK4/6 inhibitors. His laboratory uses genetic mouse models to interrogate tumor suppressor function in tissue-specific cancer contexts.