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Translational Medicine / 转化医学Hippo/YAP Pathway, Pancreatic Cancer

Joseph Bhatt

MD

🏢Johns Hopkins University School of Medicine🌐USA

Associate Professor of Gastrointestinal Oncology

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👥Biography 个人简介

Joseph Bhatt investigates Hippo-YAP pathway dysregulation in pancreatic ductal adenocarcinoma, where YAP cooperates with mutant KRAS to drive tumor progression. His research has characterized YAP-dependent transcriptional programs that promote pancreatic cancer growth and desmoplastic stroma formation. He has studied how the mechanical properties of the pancreatic tumor stroma activate YAP signaling in cancer cells. His translational work identifies YAP as a cotarget with KRAS in pancreatic cancer treatment strategies.

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🧪Research Fields 研究领域

pancreatic cancer Hippo
YAP pancreatic ductal adenocarcinoma
KRAS-YAP cooperation
pancreatic fibrosis YAP
YAP pancreatic therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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