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Translational Medicine / 转化医学Clinical Trials

José Baselga

M.D., Ph.D.

🏢Former: MSKCC, AstraZeneca🌐USA/Spain

Late Physician-Scientist (1959-2021)

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Key Papers
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Key Contributions

👥Biography 个人简介

José Baselga (1959-2021) was a transformative figure in breast cancer treatment who led clinical development of HER2-targeted therapies including trastuzumab, pertuzumab, and T-DM1. His clinical trials established the paradigm of dual HER2 blockade and antibody-drug conjugates in breast cancer. Baselga's legacy includes training generations of oncologists and advancing precision medicine.

José Baselga(1959-2021)是乳腺癌治疗领域的变革性人物,领导了HER2靶向治疗的临床开发,包括trastuzumab、pertuzumab和T-DM1。他的临床试验确立了乳腺癌中双重HER2阻断和抗体药物偶联物的范式。Baselga的遗产包括培训了几代肿瘤学家和推进精准医学。

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🧪Research Fields 研究领域

Breast Cancer乳腺癌
HER2 TherapyHER2治疗
Clinical Development临床开发

🎓Key Contributions 主要贡献

HER2-Targeted Therapy

Led clinical development of multiple HER2-targeted agents for breast cancer.

PI3K Pathway

Advanced PI3K pathway inhibitors for breast cancer treatment.

Representative Works 代表性著作

[1]

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

New England Journal of Medicine (2012)

CLEOPATRA trial establishing dual HER2 blockade.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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