Jordi Rodon Ahnert
约尔迪·罗东·阿内特
MD, PhD
Professor, Investigational Cancer Therapeutics研究性癌症治疗学教授
👥Biography 个人简介
Jordi Rodon Ahnert is an internationally recognized expert in early-phase trials of PI3K pathway inhibitors and novel targeted agents. He has led more than 50 first-in-human trials and contributed pivotal data on PI3K, mTOR, and AKT inhibitors, advancing combination strategies and resistance mechanisms.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PI3K Inhibitor Clinical Development
Led multiple first-in-human and phase I/II trials of PI3K alpha, beta, delta, and pan-PI3K inhibitors, defining dosing, toxicity, and biomarker-driven patient selection strategies.
Combination Trial Design
Developed rational combination strategies pairing PI3K pathway inhibitors with CDK4/6 inhibitors, endocrine therapy, and immunotherapy agents in biomarker-selected solid tumor populations.
Genomic Biomarker Integration
Integrated circulating tumor DNA and tumor molecular profiling into early-phase trial design, enabling dynamic monitoring of pharmacodynamic response and resistance mechanisms.
Representative Works 代表性著作
Phase I Study of the PI3K Inhibitor Copanlisib in Patients with Advanced Solid Tumors
Clinical Cancer Research (2016)
Defined dose, PK, and early efficacy signals for the pan-class I PI3K inhibitor copanlisib in solid tumor patients.
Biomarker Analysis of the SOLAR-1 Phase III Trial of Alpelisib
Annals of Oncology (2021)
Characterized resistance mechanisms and predictive biomarkers for PIK3CA-mutated breast cancer treated with alpelisib.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Alison Schram
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