Jonathan Ledermann
乔纳森·莱德曼
MD, FRCP
Emeritus Professor of Medical Oncology; Honorary Consultant Medical Oncologist肿瘤内科学荣誉教授；荣誉顾问肿瘤内科医生
👥Biography 个人简介
Jonathan Ledermann, MD, FRCP is an Emeritus Professor of Medical Oncology at UCL Cancer Institute with over three decades of leadership in ovarian cancer clinical trials. He led Study 19 (the first olaparib maintenance trial) and co-led SOLO-2, foundational studies that proved PARP inhibitor maintenance in platinum-sensitive ovarian cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Study 19: First Olaparib Maintenance Proof of Concept
Principal investigator of Study 19, the landmark phase II trial that first demonstrated olaparib maintenance therapy significantly improved progression-free survival in platinum-sensitive recurrent ovarian cancer, particularly in BRCA-mutated patients.
SOLO-2 Olaparib Phase III Confirmation
Co-led SOLO-2, the confirmatory phase III trial establishing olaparib maintenance as standard of care for BRCA-mutated, platinum-sensitive recurrent ovarian cancer.
Representative Works 代表性著作
Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer (Study 19)
New England Journal of Medicine (2012)
First randomized trial demonstrating olaparib maintenance significantly prolonged progression-free survival, with greatest benefit in BRCA-mutated patients, establishing the PARP inhibitor maintenance concept.
Olaparib tablets as maintenance therapy in patients with BRCA1/2-mutated advanced ovarian cancer (SOLO-2)
The Lancet Oncology (2017)
Confirmatory phase III trial establishing olaparib tablet formulation maintenance as standard care in BRCA-mutated, platinum-sensitive recurrent ovarian cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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