Jon Aster
MD, PhD
Professor of Pathology
👥Biography 个人简介
Jon Aster is a cancer pathologist whose mechanistic research has profoundly advanced understanding of NOTCH signaling in cancer. His studies characterized the activation mechanism of NOTCH1 and defined how gain-of-function mutations found in T-ALL constitutively activate the pathway. He has identified NOTCH pathway activation in multiple lymphoma subtypes beyond T-ALL and characterized downstream transcriptional targets. His work on NOTCH proteolytic processing has informed the development of therapeutic strategies to block pathological NOTCH activation.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-03-01 | All information from publicly available academic sources
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