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Translational Medicine / 转化医学HERV-K Expression, Retrovirus Biology

John Coffin

PhD

🏢Tufts University🌐USA

American Cancer Society Research Professor

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Key Contributions

👥Biography 个人简介

John Coffin is a founding figure in retrovirology who has made seminal contributions to understanding endogenous retroviruses in the human genome. His work on HERV-K has revealed cancer-specific expression patterns and demonstrated that HERV-K proteins are presented on the surface of cancer cells, making them targets for immunotherapy. He has provided evolutionary and functional frameworks for understanding the role of ancient retroviruses in cancer.

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🧪Research Fields 研究领域

HERV-K expression
retrovirus evolution
endogenous retrovirus biology
proviral integration
cancer retrovirology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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