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Translational Medicine / 转化医学Biliary Tract & Cholangiocarcinoma

John Bridgewater

约翰·布里奇沃特

MB BChir, PhD, FRCP

🏢UCL Cancer Institute, University College London(伦敦大学学院癌症研究所)🌐UK

Professor of Gastrointestinal Oncology; Consultant Medical Oncologist胃肠肿瘤学教授;肿瘤内科顾问医师

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

John Bridgewater, MB BChir, PhD, FRCP is Professor of Gastrointestinal Oncology at UCL Cancer Institute and a leading UK authority on cholangiocarcinoma biology and clinical research. He has advanced understanding of the molecular pathogenesis of biliary tract cancers and led major UK clinical trials, including ISAC and collaborative studies exploring novel therapeutic strategies.

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🧪Research Fields 研究领域

Cholangiocarcinoma Biology胆管癌生物学
Biliary Tract Cancer胆道肿瘤
ISAC TrialsISAC试验
Molecular Pathogenesis分子发病机制
Tumor Microenvironment肿瘤微环境
Clinical Trial Design临床试验设计

🎓Key Contributions 主要贡献

Cholangiocarcinoma Molecular Biology

Conducted foundational research into the molecular heterogeneity and tumor microenvironment of cholangiocarcinoma, identifying mechanisms of treatment resistance and informing new therapeutic strategies.

ISAC and UK Biliary Tract Cancer Trials

Led the ISAC trial and other UK-based clinical investigations of novel agents in biliary tract cancer, advancing treatment options and contributing to international trial design.

Representative Works 代表性著作

[1]

Molecular stratification of cholangiocarcinoma: correlation of the morphological classification with molecular profiling

Gut (2014)

Seminal study correlating morphological subtypes of cholangiocarcinoma with distinct molecular profiles, informing biomarker-driven clinical trial design.

🏆Awards & Recognition 奖项与荣誉

🏆ESMO Best Abstract Award — Biliary Tract Cancer
🏆Cancer Research UK Fellowship

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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