John Bhatt

John Bhatt investigates convergent evolutionary trajectories in cancer, where independent subclones arrive at similar adaptive solutions under treatment pressure. His research has characterized how different cancer cell subpopulations independently acquire resistance through parallel genetic or epigenetic changes. He has developed methods to identify convergent alterations that reveal key therapeutic vulnerabilities. His work demonstrates that despite extensive intratumor heterogeneity, cancers are constrained to limited evolutionary paths, offering opportunities for anticipatory treatment.