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Translational Medicine / 转化医学Hippo/YAP Pathway, Cancer Driver

John Bhatt

MD, PhD

🏢University of California San Francisco🌐USA

Associate Professor of Oncology

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Key Contributions

👥Biography 个人简介

John Bhatt investigates YAP as an oncogenic driver in cancers with Hippo pathway alterations, particularly mesothelioma and NF2-mutant tumors. His research has characterized how YAP amplification and Hippo pathway loss converge to drive oncogenic transcription programs. He has evaluated TEAD inhibitors and other strategies to block oncogenic YAP activity in cancer cells. His translational studies are advancing YAP inhibition into clinical trials for mesothelioma and other Hippo-deficient tumors.

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🧪Research Fields 研究领域

YAP amplification in cancer
mesothelioma Hippo loss
therapeutic targeting YAP
TEAD inhibitors
Hippo pathway mutations

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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