Johanna Joyce

Johanna Joyce at the Ludwig Institute in Lausanne is a leader in tumor microenvironment biology with particular expertise in brain tumors, which represent quintessential immune cold malignancies. Her research has characterized the immunosuppressive microenvironment of glioblastoma and how tumor-associated microglia and macrophages maintain immune exclusion. She has identified therapeutic strategies to remodel the cold brain tumor microenvironment through macrophage repolarization and stromal modification. Her comprehensive TME research spanning multiple cold tumor types has contributed to rational combination strategies to improve immunotherapy access in immune excluded tumors.