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Translational Medicine / 转化医学Oncolytic Virus, Combination Oncolytic IO Trials

Johann de Bono

MD, PhD, FRCP

🏢Royal Marsden Hospital / Institute of Cancer Research🌐UK

Professor of Experimental Cancer Medicine

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👥Biography 个人简介

Johann de Bono has championed early-phase trials of novel intratumoral and systemic immunotherapy approaches including oncolytic viruses in combination with checkpoint inhibitors. His laboratory has studied the innate immune activation mechanisms underlying oncolytic virus efficacy and identified predictive biomarkers for response. He has designed innovative phase I/II trial platforms enabling rapid evaluation of novel oncolytic combinations.

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🧪Research Fields 研究领域

oncolytic virus IO combination trials
intratumoral immunotherapy clinical development
solid tumor innate immunity activation
STING agonist combination oncolytic
early phase oncology trials design

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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