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Translational Medicine / 转化医学TGF-beta Signaling, Metastasis Biology

Joan Massague

PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Director, Sloan Kettering Institute

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Key Contributions

👥Biography 个人简介

Joan Massague elucidated the TGF-beta/Smad signaling pathway and its dual role as tumor suppressor and metastasis promoter in cancer. His systematic dissection of organ-specific metastasis programs revealed how cancer cells acquire organ tropism through distinct gene expression programs. His work on metastatic dormancy and the mechanisms by which disseminated cancer cells reactivate has transformed understanding of the metastatic cascade.

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🧪Research Fields 研究领域

TGF-beta signaling cancer
metastasis organotropism
Smad pathway
dormancy metastatic cells
metastasis suppressor genes

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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