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Translational Medicine / 转化医学METTL3/METTL14 Writers, AML

Jianjun Chen

PhD

🏢City of Hope National Medical Center🌐USA

Professor of Systems Biology

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Key Contributions

👥Biography 个人简介

Jianjun Chen has been instrumental in establishing the oncogenic role of m6A writer proteins METTL3 and METTL14 in acute myeloid leukemia. His work demonstrated that these enzymes maintain leukemia stem cell self-renewal by methylating key mRNAs involved in differentiation and apoptosis. He has pioneered the development of METTL3 inhibitors as a new class of anti-leukemia therapeutics.

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🧪Research Fields 研究领域

METTL3 leukemia
METTL14 AML
m6A writer complex
leukemia stem cells
RNA methylation therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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