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Translational Medicine / 转化医学NSCLC, ALK Compound Mutations

Jhanelle E. Gray

MD

🏢Moffitt Cancer Center🌐USA

Senior Member and Chair, Department of Thoracic Oncology

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👥Biography 个人简介

Jhanelle Gray is an expert thoracic oncologist and clinical investigator focusing on mechanisms of resistance to ALK inhibitors and strategies to overcome compound ALK mutations that arise through sequential therapy. She has contributed to landmark studies of lorlatinib demonstrating activity against G1202R and other compound resistance mutations. Her research program characterizes the evolutionary landscape of ALK-positive NSCLC under therapeutic pressure. She leads phase I/II trials of next-generation therapies for patients with compound ALK mutations.

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🧪Research Fields 研究领域

ALK compound mutations
sequential ALK inhibitor therapy
ALK solvent-front mutations
G1202R ALK resistance
lorlatinib compound mutation activity

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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