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Translational Medicine / 转化医学Telomere Biology, Cancer Therapeutics

Jerry Shay

PhD

🏢UT Southwestern Medical Center🌐USA

Professor and Vice Chairman of Cell Biology

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👥Biography 个人简介

Jerry Shay is a leading expert on telomere biology in cancer and has pioneered the development of telomerase inhibitors as cancer therapy. He demonstrated that more than 90% of human cancers express telomerase, making it a near-universal cancer target. His work on imetelstat (GRN163L) led to clinical trials in multiple cancer types including myelofibrosis and myelodysplastic syndromes. He has authored landmark studies defining the role of telomere shortening in cancer initiation.

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🧪Research Fields 研究领域

telomerase cancer therapy
telomere length cancer
immortalization
GRN163L
solid tumor telomeres

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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