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Translational Medicine / 转化医学Imetelstat, Telomerase Inhibitor Therapy

Jerry Shay

PhD

🏢UT Southwestern Medical Center🌐USA

Distinguished Teaching Professor of Cell Biology

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Key Contributions

👥Biography 个人简介

Jerry Shay has been instrumental in translating telomere biology into cancer therapeutics, particularly through the development and clinical advancement of imetelstat, a telomerase inhibitor now approved for myelodysplastic syndromes and myelofibrosis. His decades of work establishing telomerase as a nearly universal cancer target laid the foundation for telomerase-directed therapies. He has developed critical assays for measuring telomerase activity and telomere length in clinical settings.

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🧪Research Fields 研究领域

imetelstat telomerase inhibitor
telomerase cancer therapy
hTERT targeting
MDS myelofibrosis telomerase
telomere length cancer prognosis

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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