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Translational Medicine / 转化医学CLL, BTK Resistance, Acalabrutinib

Jennifer Woyach

MD

🏢Ohio State University Comprehensive Cancer Center🌐USA

Associate Professor of Medicine

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👥Biography 个人简介

Jennifer Woyach at Ohio State is an expert in BTK inhibitor resistance in CLL and has contributed to the development of next-generation BTK inhibitors including acalabrutinib. Her research characterizing acquired BTK and PLCG2 mutations that cause ibrutinib resistance, and her clinical trials of more selective BTK inhibitors like acalabrutinib and zanubrutinib designed to overcome some resistance mechanisms, have shaped the BTK inhibitor landscape in CLL.

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🧪Research Fields 研究领域

CLL
acalabrutinib
next-generation BTK inhibitors
BTK resistance mutations
ibrutinib resistance CLL

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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