Jennifer Brown
珍妮弗·布朗
MD, PhD
Director, CLL Center; Associate Professor of Medicine, Harvard Medical SchoolCLL中心主任兼哈佛医学院医学副教授
👥Biography 个人简介
Dr. Jennifer Brown leads the CLL Center at Dana-Farber and is a leading authority on BTK inhibitor resistance mechanisms and next-generation CLL therapies. She played a key role in the ALPINE trial establishing zanubrutinib's superiority over ibrutinib in relapsed/refractory CLL.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BTK Inhibitor Resistance and ALPINE Trial
Contributed significantly to the ALPINE trial demonstrating zanubrutinib's superior PFS and lower atrial fibrillation rates versus ibrutinib in relapsed/refractory CLL, supporting zanubrutinib as the preferred BTK inhibitor.
CLL Resistance Biology and Novel Combinations
Characterized molecular mechanisms of resistance to BTK inhibitors including C481 mutations and BCL2 pathway alterations, guiding rational combination strategies to overcome and prevent resistance in CLL.
Representative Works 代表性著作
Zanubrutinib versus Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPINE)
New England Journal of Medicine (2023)
Phase 3 ALPINE trial demonstrating zanubrutinib superiority over ibrutinib in r/r CLL with better efficacy and safety.
Mechanisms of Resistance to idelalisib and Ibrutinib in Chronic Lymphocytic Leukemia
New England Journal of Medicine (2016)
Identified BTK and PLCG2 mutations mediating acquired resistance to BTK and PI3K inhibitors, providing mechanistic basis for next-generation therapies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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