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Translational Medicine / 转化医学Histone Modifications, Cancer Transcription

Jennifer Bhatt

PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Associate Professor of Biochemistry

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👥Biography 个人简介

Jennifer Bhatt studies how histone-modifying enzyme mutations reshape the cancer transcriptome and drive oncogenesis. Her research characterized KMT2D (MLL4) loss-of-function mutations in lymphoma as epigenetic tumor suppressors that regulate super-enhancer activity. She has also studied NSD2 overexpression in multiple myeloma and its role in H3K36 dimethylation-driven oncogene activation. Her work on oncohistone H3.3 mutations in diffuse intrinsic pontine glioma revealed that histone mutations themselves can directly drive cancer.

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🧪Research Fields 研究领域

H3K4 methylation cancer
KMT2D MLL mutations
NSD2 histone methyltransferase
H3.3 mutations glioma
histone oncoproteins

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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