Jeffrey Weber
杰弗里·韦伯
MD, PhD
Deputy Director, Professor of Medicine副主任，医学教授
👥Biography 个人简介
Jeffrey Weber is a melanoma immunotherapy leader at NYU Langone who ran pivotal early trials of ipilimumab and nivolumab. His research on neoadjuvant immunotherapy, adjuvant checkpoint blockade, and predictive biomarkers has substantially advanced the field of melanoma management.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Ipilimumab Clinical Development
Conducted early-phase ipilimumab trials establishing anti-CTLA-4 as the first immune checkpoint therapy to show an overall survival benefit in metastatic melanoma.
Adjuvant Nivolumab in Melanoma
Led CheckMate 238 trial demonstrating nivolumab superiority over ipilimumab as adjuvant therapy in resected stage IIIB-IV melanoma, with improved RFS and tolerability.
Immunotherapy Biomarker Research
Identified gut microbiome composition, tumor mutational burden, and immune gene expression profiles as predictors of checkpoint immunotherapy response and toxicity in melanoma.
Representative Works 代表性著作
Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma (CheckMate 238)
New England Journal of Medicine (2017)
Established nivolumab as the preferred adjuvant immunotherapy over ipilimumab in resected high-risk melanoma.
Phase I/II Study of Ipilimumab Monotherapy in Patients with Metastatic Melanoma
Journal of Clinical Oncology (2008)
Early clinical trial establishing durable antitumor activity of anti-CTLA-4 ipilimumab in advanced melanoma.
Gut Microbiome Diversity and Checkpoint Immunotherapy Response in Melanoma
Science (2018)
Demonstrated that gut microbiome composition influences response to anti-PD-1 therapy in melanoma patients.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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