Jeffrey Engelman
杰弗里·恩格尔曼
MD, PhD
President, Oncology Research肿瘤研究总裁
👥Biography 个人简介
Jeffrey Engelman is a translational oncologist who made foundational discoveries on mechanisms of acquired resistance to EGFR inhibitors in lung cancer. His identification of MET amplification as a major bypass resistance mechanism to EGFR TKIs fundamentally shaped understanding of adaptive tumor evolution and led to rational combination strategies. As a research leader at MGH and subsequently at Novartis, Engelman has bridged bench discovery to clinical biomarker development, driving ctDNA-based companion diagnostics and resistance monitoring platforms used in global oncology trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
MET Amplification in EGFR Resistance
Discovered that MET amplification drives acquired resistance to EGFR inhibitors in NSCLC, leading directly to clinical trials of EGFR/MET dual blockade and reshaping resistance biomarker testing.
Bypass Signaling Resistance Framework
Established the conceptual framework that tumors develop resistance through bypass track activation rather than target modification alone, guiding combination resistance monitoring strategies.
Representative Works 代表性著作
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Science (2007)
Landmark discovery of MET-mediated bypass resistance to EGFR inhibitors.
Acquired Resistance to EGFR Kinase Inhibitors Associated with a Novel T790M Mutation
PLOS Medicine (2006)
Early characterization of T790M gatekeeper mutation in EGFR TKI resistance.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 杰弗里·恩格尔曼 的研究动态
Follow Jeffrey Engelman's research updates
留下邮箱，当我们发布与 Jeffrey Engelman（Novartis Oncology）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment