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Translational Medicine / 转化医学IO Resistance, Melanoma Immunotherapy

Jedd Wolchok

MD, PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Chief of Melanoma and Immunotherapeutics Service

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Key Contributions

👥Biography 个人简介

Jedd Wolchok is a global leader in cancer immunotherapy and a pioneer in the development of ipilimumab and nivolumab combination therapy for melanoma. His research has defined primary and acquired resistance mechanisms to immune checkpoint blockade. He led the landmark CheckMate 067 trial demonstrating superior outcomes of combination checkpoint inhibition. His work bridges translational biology with clinical practice in IO resistance.

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🧪Research Fields 研究领域

immune checkpoint resistance
melanoma immunotherapy
combination IO
anti-CTLA4
anti-PD1

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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