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Translational Medicine / 转化医学Durvalumab Lung Cancer, PACIFIC Trial

Jean-Charles Soria

MD, PhD

🏢AstraZeneca (formerly Institut Gustave Roussy)🌐France

Chief Medical Officer and Vice President of Global Development

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Key Contributions

👥Biography 个人简介

Jean-Charles Soria played a central role in the clinical development of durvalumab and the landmark PACIFIC trial establishing durvalumab as standard consolidation therapy after chemoradiotherapy for stage III unresectable NSCLC. The PACIFIC trial demonstrated unprecedented improvement in progression-free and overall survival in stage III NSCLC patients treated with durvalumab after chemoradiation, transforming the standard of care for this patient population. He has led multiple pivotal immunotherapy trials in lung cancer and other tumor types, advancing the clinical development of several checkpoint inhibitors. His translational and clinical research leadership has been central to the expansion of immunotherapy into earlier stages of lung cancer.

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🧪Research Fields 研究领域

PACIFIC trial durvalumab
stage III NSCLC immunotherapy
durvalumab lung cancer
anti-PD-L1 lung
early-stage NSCLC immunotherapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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