Jayanta Debnath

Jayanta Debnath is a leading researcher on the role of autophagy in breast cancer progression, particularly demonstrating that autophagy enables cancer cells to survive detachment from the extracellular matrix, a key step in anoikis resistance and metastasis. His laboratory has developed three-dimensional mammary acinar culture systems that revealed how autophagy contributes to lumen formation and epithelial homeostasis. He has pioneered the concept of secretory autophagy in tumor-immune interactions. His work has provided critical insights into how autophagy modulation might enhance breast cancer therapy.