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Translational Medicine / 转化医学DLBCL CAR-T Second-Line, ZUMA-7 TRANSFORM

Jason Westin

MD, MS

🏢MD Anderson Cancer Center🌐USA

Associate Professor, Lymphoma/Myeloma Department

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👥Biography 个人简介

Jason Westin is a DLBCL clinical investigator who co-led the TRANSFORM trial demonstrating superior outcomes with lisocabtagene maraleucel (liso-cel) versus salvage chemotherapy plus autologous stem cell transplant in second-line relapsed/refractory DLBCL. This work, alongside ZUMA-7, established CAR-T cell therapy as the new standard of care for early relapsed DLBCL. He investigates patient selection for CAR-T versus bispecific antibodies, access barriers, and DLBCL management in frail elderly patients. He leads the MD Anderson lymphoma clinical trials portfolio.

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🧪Research Fields 研究领域

ZUMA-7 axicabtagene second-line DLBCL
TRANSFORM lisocabtagene second-line DLBCL
CAR-T early DLBCL relapse standard of care
DLBCL second-line CAR-T versus autologous transplant
DLBCL outcomes elderly patients

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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