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Translational Medicine / 转化医学EGFR Exon 20 Insertion Lung Cancer

Pasi Janne

MD, PhD

🏢Dana-Farber Cancer Institute🌐USA

Professor of Medicine

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Key Contributions

👥Biography 个人简介

Pasi Janne is a leading investigator of EGFR exon 20 insertion mutations in non-small cell lung cancer. His laboratory and clinical work defined sensitivity patterns of exon 20 variants to novel tyrosine kinase inhibitors. He led pivotal trials establishing mobocertinib and poziotinib clinical activity in this underserved molecular subtype.

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🧪Research Fields 研究领域

EGFR exon 20 insertions
Targeted therapy resistance
Mobocertinib
Lung adenocarcinoma
Biomarker-driven trials

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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