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Translational Medicine / 转化医学Cancer Cytogenetics, Philadelphia Chromosome

Janet Rowley

MD

🏢University of Chicago🌐USA

Blum-Riese Distinguished Service Professor (posthumous)

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👥Biography 个人简介

Janet Rowley (1925-2013) made the transformative discovery that cancer cells contain specific chromosomal translocations, particularly the t(9;22) Philadelphia chromosome in CML. Her meticulous cytogenetic work in the 1970s established that cancer is a genetic disease with specific chromosomal abnormalities, directly leading decades later to the development of imatinib targeting BCR-ABL. She is considered the mother of modern cancer cytogenetics.

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🧪Research Fields 研究领域

Philadelphia chromosome
BCR-ABL
chromosomal translocations
cancer cytogenetics
leukemia biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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