Jan Bhatt

Jan Bhatt investigates extracellular matrix remodeling during tumor progression, with expertise in how cancer cells degrade and restructure basement membranes to enable invasion and how the altered matrisome composition influences immune cell infiltration and function. His research has developed matrisome profiling approaches to characterize tumor-specific ECM signatures that correlate with patient prognosis and treatment response. He has shown that ECM biomechanical properties regulate immune cell migration and activation within the tumor microenvironment. His work bridges matrix biology with cancer immunology.