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Translational Medicine / 转化医学Pediatric Cancer Genomics, ALL Biology

James Downing

MD

🏢St. Jude Children's Research Hospital🌐USA

President and CEO

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👥Biography 个人简介

James Downing led the landmark Pediatric Cancer Genome Project at St. Jude Children's Research Hospital, providing comprehensive genomic characterization of pediatric cancers. His work identified new molecular subtypes of pediatric ALL and solid tumors that are now used to guide risk stratification and treatment. He discovered the ETV6-RUNX1 translocation and contributed to understanding ERG deletions in B-cell ALL. As CEO of St. Jude, he continues to champion genomics-driven advances in pediatric cancer research globally.

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🧪Research Fields 研究领域

pediatric cancer genomics
ALL molecular subtypes
St. Jude PCGP
ETS fusion ALL
pediatric cancer whole genome sequencing

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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