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Translational Medicine / 转化医学Milestone, Checkpoint Immunotherapy

James Allison

PhD

🏢The University of Texas MD Anderson Cancer Center🌐USA

Professor and Chair, Department of Immunology; Nobel Laureate

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👥Biography 个人简介

James Allison is a Nobel Prize-winning immunologist (2018) whose discovery that blocking CTLA-4 unleashes immune attack on cancer led directly to the development of ipilimumab, the first approved immune checkpoint inhibitor. His foundational basic science at UC Berkeley and subsequent translational work opened the entire field of cancer immunotherapy. His work set the paradigm for PD-1/PD-L1 blockade and the immunotherapy revolution that has transformed oncology.

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🧪Research Fields 研究领域

CTLA-4 checkpoint blockade
ipilimumab development
cancer immunotherapy Nobel Prize
T-cell activation cancer
immune checkpoint milestone

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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